Largest ever independent study into cannabis use

Source: BBC.com | Author: BBC | Aug 30, 2022

A £2.5 million study into the effects of cannabis on the brain has been launched by a London university.

The Cannabis & Me study will research environmental and biological factors behind the different effects people experience when using cannabis.

Dr Marta di Forti
Dr Marta di Forti wants to investigate genetic interactions with the drug

King’s College London want 6,000 people to take part in the investigation, which would be the largest independent study of its kind.

Researchers said the funding from the Medical Research Council would help develop greater understanding of the drug, estimated to be used by 200 million people across the world.

More research is needed about how the drug interacts with the brain so doctors can be more confident when considering prescribing medical cannabis, said lead researcher, Dr Di Forti.

“Cannabis is consumed daily by many recreationally but also for medicinal reasons,” she said.

“But in the UK, the prescription of medicinal cannabis remains rare.

“Our study aims to provide data and tools that can make physicians in the UK and across the world more confident, where appropriate, in prescribing cannabis safely.”

The aim is to understand the link between a user’s biological makeup and the effect cannabis has on them.

Cannabis medicine production line
Production of cannabis-infused medicine at the Government Pharmaceutical Organization in Thailand

Researchers will use a combination of virtual reality, psychological and cognitive analysis, and DNA testing.

They will also look at epigenetics in participants, which is how behaviour and environment can impact the way genes work.

Dr Di Forti said she was particularly interested in uncovering any markers connected to potential problems in users, for example mental health or social problems.

The team is now looking for participants between the ages of 18-45 living in the London area, who are either currently using cannabis or have used it less than three times or never before.

The first step for participants is filling out a 40-minute survey online, external.

Study: History of Marijuana Use Not Associated with Increased Heart Attack Risk

Source: Norml.org | Author: Norml | Feb 17, 2022

New York, NY: Cannabis smoke exposure is not positively associated with an increased risk of myocardial infarction, according to data published in the journal Cureus

A pair of researchers with the Icahn School of Medicine at Mount Sinai in New York City assessed the association between a history of cannabis smoking and heart attack in a cohort of over 500,000 subjects from the United Kingdom.

Researchers identified an inverse association between cannabis use and incidences of myocardial infarction, and they found no correlation between marijuana consumption and heart attack severity. 

“With marijuana use, MI [myocardial infarction] decreased,” authors concluded. They further acknowledged: “The association of marijuana use with reduced risk of MI is not entirely in accord with current assumptions about the cardiac effects of marijuana. … Further studies are warranted.”

Studies assessing the association between cannabis use and cardiovascular health have been inconsistent, with some studies finding an increased risk of stroke and other cardiovascular diseases among marijuana consumers while others report either no risk or provide evidence of possible cardioprotection

Full text of the study, “Marijuana and myocardial infarction in the UK Biobank cohort,” appears in Cureus.